HIV-1 remodels the nuclear pore complex
نویسندگان
چکیده
منابع مشابه
HIV-1 remodels the nuclear pore complex
Human immunodeficiency virus type 1 (HIV-1) commandeers host cell proteins and machineries for its replication. Our earlier work showed that HIV-1 induced the cytoplasmic retention of nucleocytoplasmic shuttling and ribonucleic acid (RNA)-binding proteins. This retention is dependent on nuclear export of the viral genomic RNA and on changes in the localization and expression level of the nucleo...
متن کاملViral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex.
Replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells depends critically on import of the viral preintegration complex into the nucleus. Recent evidence suggests that viral protein R (Vpr) plays a key regulatory role in this process by binding to karyopherin alpha, a cellular receptor for nuclear localization signals, and increasing its affinity for the nuclear locali...
متن کاملThe nuclear pore complex
M OLECULAR trafficking between the nucleus and the cytoplasm of interphase eukaryotic cells occurs via the nuclear pore complexes (NPCs), 1 organelles with a roughly cylindrical shape (~,120 um in diameter and ~70-um high) that are embedded in the double-membraned nuclear envelope (NE). The NPC allows passive diffusion of ions and small molecules through an aqueous channel with a physical diame...
متن کاملThe nuclear pore complex.
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field. Structural studies employing high resolution EM have revealed a detailed view of the three-dimensional organization of...
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The HIV-1 central DNA Flap acts as a cis-acting determinant of HIV-1 genome nuclear import. Indeed, DNA-Flap re-insertion within lentiviral-derived gene transfer vectors strongly stimulates gene transfer efficiencies. In this study, we sought to understand the mechanisms by which the central DNA Flap mediates HIV-1 nuclear import. Here, we show that reverse transcription (RT degrees) occurs wit...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201008064